Th2 Cytokines Down-Regulate TLR Expression and Function in Human Intestinal Epithelial Cells
نویسندگان
چکیده
منابع مشابه
Th2 cytokines down-regulate TLR expression and function in human intestinal epithelial cells.
TLRs serve important immune and nonimmune functions in human intestinal epithelial cells (IECs). Proinflammatory Th1 cytokines have been shown to promote TLR expression and function in IECs, but the effect of key Th2 cytokines (IL-4, IL-5, IL-13) on TLR signaling in IECs has not been elucidated so far. We stimulated human model IECs with Th2 cytokines and examined TLR mRNA and protein expressio...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2006
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.176.10.5805